This guide, written by Mgr. Barbara Kordíková, PhD. Department of Languages, Faculty of Natural Sciences, Comenius University from Bratislava, provides a comprehensive approach to designing and executing semi-structured interviews for qualitative research. It covers the pros and cons of semi-structured interviews, setting clear goals and objectives, developing effective interview questions, selecting and engaging interviewees, conducting interviews, as well as transcribing, editing, and processing collected data. Ideal for new researchers, this resource aims to support the thoughtful and rigorous application of interview techniques in qualitative studies.